New recipes

Enzyme from Nattō Prevents Blood Clots, Helps Blood Flow

Enzyme from Nattō Prevents Blood Clots, Helps Blood Flow


The enzyme, which can be used to reduce the danger of blood clots, could be added to a number of product formulations

Scientists in Japan have found that nattokinase, an enzyme derived from nattō, helps prevent the formation of blood clots.

Nattō, the fermented Japanese soybean dish popular in its home country but polarizing elsewhere — for its distinct flavor and smell and slimy texture — may be a taste worth acquiring, even for picky eaters. According to new research from Japan Bio Science Laboratory, an enzyme derived from nattō, sold as NSK-SD in a number of countries including the United States, is capable of breaking down dangerous blood clots and enhancing blood flow.

In a double-blind study of 12 healthy males, each subject received either a single dose of the nattokinase enzyme or a placebo, with these roles later switched. Over a period of eight hours, researchers found that a single dose simultaneously enhanced fibrinolysis, a natural process by which blood clots are broken down, as well as anticoagulation, the prevention of blood clotting.

Although researchers say that further studies of the enzyme are necessary, Japan Bio Science Laboratory told NutraIngredients-USA that the company is “eager to partner with brands that do not yet have NSK-SD in their formulas and share in the cost of producing clinical work on their proprietary formulas.”

Among the uses of the enzyme, nattokinase could potentially be used in a number of applications to prevent blood clots, including the protection of women on birth control pills — the use of which often raises the risk of blood clots — as well as elderly patients at risk for strokes and heart attacks, according to Vincent Hackel, the president of JBSL-USA, a member of Japan’s NattoKinase Association.

“We still feel products directed to reducing hypertension, reducing inflammation, and improving circulation, with the clinical evidence to back them up, are underrepresented in the professional, retail, and multi-level marketing channels and hope to forge new partnerships in these important areas,” Hackel told NutraIngredients.


What is Nattokinase?

Nattokinase nat-oh-KAI-nase is an enzyme that was discovered within the popular Japanese food natto, a fermented soybean cheese. It is produced by a probiotic bacteria Bacillus subtilis found to grow naturally during the fermentation of soybeans. While the nattokinase probiotic was found to exist on soybeans the extracted enzyme does not actually contain soy or soy particles itself. Making it safe for individuals trying to avoid soy products to consume. This enzyme is well-researched and known for its ability to dissolve fibrin, a strong protein that assists with the blood-clotting process.

In fact, nattokinase has been found to be four times stronger than human plasmin, the native enzyme that breaks down fibrin and blood clots. Nattokinase currently holds the title for the most powerful fibrin-dissolving enzyme.

Let’s look at the different ways nattokinase can condition blood to support cardiovascular health. The three pillars of ideal blood conditioning require normal ranges of: clotting, pressure, and viscosity.

Nattokinase has an unmatched ability to break down proteins, particularly fibrin. Fibrin is the sticky webs that aggregate blood cells.

In a clinical study published by the Japan Bio Science Laboratory Co. Ltd, oral supplementation of nattokinase significantly increased the ability of other substances in the bloodstream to break down blood clots for two to eight hours. This was not the case for regular soybean supplementation the nattokinase enzyme provided the defining benefit in the participants’ bloodstream.

Furthermore, a 2003 study concerning blood clots in the leg, concluded that people who were at risk for clotting and preparing for a long flight – and also orally consumed nattokinase – experienced a significant reduction of blood clots and swelling in their arms and legs.

Circulation and Blood Flow

Nattokinase has an impressive track record for its ability to improve blood flow by breaking down fibrin. This aptly positions it for assisting with cardiovascular concerns, such as arterial elasticity, build-up of fibrin, and unfavorable hemorheology (flow).

Certain cardiovascular circumstances are hastened by reduced blood flow to vital organs. These may be prompted by increased fibrinogen (fibrin’s precursor), elasticity of the arteries, red blood cell clumping which thickens the blood, and blood clots.

The ability of nattokinase to dissolve excess fibrinogen as well as fibrin, makes it a heart-healthy supplement.

Heart Attention: A Nattokinase Clinical Study

In a 2017 clinical trial with over 80 participants who had carotid artery thickness and plaque buildup in the carotid artery (both indicators of atherosclerosis), the group who was given 6,000 FU of nattokinase over a 26-week period experienced a 36.6% reduction in plaque size compared to only an 11.5% reduction for the group who was given 20 mg of a statin.

Both groups noticed lower levels of bad cholesterol (LDL-C), total cholesterol, and triglycerides (fats), however, only the participants who were administered nattokinase were found to have heightened levels of good cholesterol (HDL-C).

These improvements were attributed to the ability of nattokinase to dissolve fibrin and fibrinogen, target thickened arteries and blood clots, and augment the activity of other substances in the body that have similar functions. Additionally, nattokinase is a proven alternative to traditional therapies when addressing cardiovascular risk factors associated with heightened fibrin levels.

The Heart Healthy Enzyme

Finally, research has shown that nattokinase reduces red blood cell clumping and undesirable blood clots by targeting both fibrin and fibrinogen. The result is improved blood flow. Cleaner blood is better for your body – and that’s how nattokinase helps to keep your body running in tip-top shape!

Nattokinase: The Lower Pressure Agent

Nattokinase’s ability to restore proper blood flow is one benefit that leads to another: lower blood pressure.

Clinical research by the Japan Functional Food Research Association documented an average 10.9% reduction of systolic blood pressure as well as an average 9.7% for diastolic pressure with nattokinase supplementation, helping to restore proper blood flow.

In another study with 39 individuals whose systolic blood pressure ranged from 130 mmHg to 159 mmHg, participants who were supplemented with nattokinase for 8 weeks, ended up with both lower systolic and diastolic blood pressure, compared to the placebo group. This demonstrates that nattokinase supports healthy blood pressure levels for people with elevated blood pressure approaching out of range.

Why Add Nattokinase to Your Supplement Routine?

According to The Applied Microbiology and Biotechnology, nattokinase remains stable in the GI tract and is a safe, strong nutraceutical and dietary supplement without serious adverse side effects.

Whether you’re battling – or susceptible to – clots, elevated blood pressure, cardiovascular problems, stiffened arteries, or excess fibrin build-up, nattokinase is a safe, effective supplement to assist with normal blood flow and fibrin degradation.

Where to find nattokinase

The following products have high concentrations of nattokinase, which assist in dissolving excess fibrin for better joint mobility, cleaner blood, and overall well-being.

Nattovena – Your pure nattokinase supplement for potent fibrin-degrading ability.

Neprinol – Cleanses the blood and supports proper joint and circulatory function.

Fibrovera – Supports normal fibrin activity through healthy hormone levels for women.


What is Nattokinase?

Nattokinase nat-oh-KAI-nase is an enzyme that was discovered within the popular Japanese food natto, a fermented soybean cheese. It is produced by a probiotic bacteria Bacillus subtilis found to grow naturally during the fermentation of soybeans. While the nattokinase probiotic was found to exist on soybeans the extracted enzyme does not actually contain soy or soy particles itself. Making it safe for individuals trying to avoid soy products to consume. This enzyme is well-researched and known for its ability to dissolve fibrin, a strong protein that assists with the blood-clotting process.

In fact, nattokinase has been found to be four times stronger than human plasmin, the native enzyme that breaks down fibrin and blood clots. Nattokinase currently holds the title for the most powerful fibrin-dissolving enzyme.

Let’s look at the different ways nattokinase can condition blood to support cardiovascular health. The three pillars of ideal blood conditioning require normal ranges of: clotting, pressure, and viscosity.

Nattokinase has an unmatched ability to break down proteins, particularly fibrin. Fibrin is the sticky webs that aggregate blood cells.

In a clinical study published by the Japan Bio Science Laboratory Co. Ltd, oral supplementation of nattokinase significantly increased the ability of other substances in the bloodstream to break down blood clots for two to eight hours. This was not the case for regular soybean supplementation the nattokinase enzyme provided the defining benefit in the participants’ bloodstream.

Furthermore, a 2003 study concerning blood clots in the leg, concluded that people who were at risk for clotting and preparing for a long flight – and also orally consumed nattokinase – experienced a significant reduction of blood clots and swelling in their arms and legs.

Circulation and Blood Flow

Nattokinase has an impressive track record for its ability to improve blood flow by breaking down fibrin. This aptly positions it for assisting with cardiovascular concerns, such as arterial elasticity, build-up of fibrin, and unfavorable hemorheology (flow).

Certain cardiovascular circumstances are hastened by reduced blood flow to vital organs. These may be prompted by increased fibrinogen (fibrin’s precursor), elasticity of the arteries, red blood cell clumping which thickens the blood, and blood clots.

The ability of nattokinase to dissolve excess fibrinogen as well as fibrin, makes it a heart-healthy supplement.

Heart Attention: A Nattokinase Clinical Study

In a 2017 clinical trial with over 80 participants who had carotid artery thickness and plaque buildup in the carotid artery (both indicators of atherosclerosis), the group who was given 6,000 FU of nattokinase over a 26-week period experienced a 36.6% reduction in plaque size compared to only an 11.5% reduction for the group who was given 20 mg of a statin.

Both groups noticed lower levels of bad cholesterol (LDL-C), total cholesterol, and triglycerides (fats), however, only the participants who were administered nattokinase were found to have heightened levels of good cholesterol (HDL-C).

These improvements were attributed to the ability of nattokinase to dissolve fibrin and fibrinogen, target thickened arteries and blood clots, and augment the activity of other substances in the body that have similar functions. Additionally, nattokinase is a proven alternative to traditional therapies when addressing cardiovascular risk factors associated with heightened fibrin levels.

The Heart Healthy Enzyme

Finally, research has shown that nattokinase reduces red blood cell clumping and undesirable blood clots by targeting both fibrin and fibrinogen. The result is improved blood flow. Cleaner blood is better for your body – and that’s how nattokinase helps to keep your body running in tip-top shape!

Nattokinase: The Lower Pressure Agent

Nattokinase’s ability to restore proper blood flow is one benefit that leads to another: lower blood pressure.

Clinical research by the Japan Functional Food Research Association documented an average 10.9% reduction of systolic blood pressure as well as an average 9.7% for diastolic pressure with nattokinase supplementation, helping to restore proper blood flow.

In another study with 39 individuals whose systolic blood pressure ranged from 130 mmHg to 159 mmHg, participants who were supplemented with nattokinase for 8 weeks, ended up with both lower systolic and diastolic blood pressure, compared to the placebo group. This demonstrates that nattokinase supports healthy blood pressure levels for people with elevated blood pressure approaching out of range.

Why Add Nattokinase to Your Supplement Routine?

According to The Applied Microbiology and Biotechnology, nattokinase remains stable in the GI tract and is a safe, strong nutraceutical and dietary supplement without serious adverse side effects.

Whether you’re battling – or susceptible to – clots, elevated blood pressure, cardiovascular problems, stiffened arteries, or excess fibrin build-up, nattokinase is a safe, effective supplement to assist with normal blood flow and fibrin degradation.

Where to find nattokinase

The following products have high concentrations of nattokinase, which assist in dissolving excess fibrin for better joint mobility, cleaner blood, and overall well-being.

Nattovena – Your pure nattokinase supplement for potent fibrin-degrading ability.

Neprinol – Cleanses the blood and supports proper joint and circulatory function.

Fibrovera – Supports normal fibrin activity through healthy hormone levels for women.


What is Nattokinase?

Nattokinase nat-oh-KAI-nase is an enzyme that was discovered within the popular Japanese food natto, a fermented soybean cheese. It is produced by a probiotic bacteria Bacillus subtilis found to grow naturally during the fermentation of soybeans. While the nattokinase probiotic was found to exist on soybeans the extracted enzyme does not actually contain soy or soy particles itself. Making it safe for individuals trying to avoid soy products to consume. This enzyme is well-researched and known for its ability to dissolve fibrin, a strong protein that assists with the blood-clotting process.

In fact, nattokinase has been found to be four times stronger than human plasmin, the native enzyme that breaks down fibrin and blood clots. Nattokinase currently holds the title for the most powerful fibrin-dissolving enzyme.

Let’s look at the different ways nattokinase can condition blood to support cardiovascular health. The three pillars of ideal blood conditioning require normal ranges of: clotting, pressure, and viscosity.

Nattokinase has an unmatched ability to break down proteins, particularly fibrin. Fibrin is the sticky webs that aggregate blood cells.

In a clinical study published by the Japan Bio Science Laboratory Co. Ltd, oral supplementation of nattokinase significantly increased the ability of other substances in the bloodstream to break down blood clots for two to eight hours. This was not the case for regular soybean supplementation the nattokinase enzyme provided the defining benefit in the participants’ bloodstream.

Furthermore, a 2003 study concerning blood clots in the leg, concluded that people who were at risk for clotting and preparing for a long flight – and also orally consumed nattokinase – experienced a significant reduction of blood clots and swelling in their arms and legs.

Circulation and Blood Flow

Nattokinase has an impressive track record for its ability to improve blood flow by breaking down fibrin. This aptly positions it for assisting with cardiovascular concerns, such as arterial elasticity, build-up of fibrin, and unfavorable hemorheology (flow).

Certain cardiovascular circumstances are hastened by reduced blood flow to vital organs. These may be prompted by increased fibrinogen (fibrin’s precursor), elasticity of the arteries, red blood cell clumping which thickens the blood, and blood clots.

The ability of nattokinase to dissolve excess fibrinogen as well as fibrin, makes it a heart-healthy supplement.

Heart Attention: A Nattokinase Clinical Study

In a 2017 clinical trial with over 80 participants who had carotid artery thickness and plaque buildup in the carotid artery (both indicators of atherosclerosis), the group who was given 6,000 FU of nattokinase over a 26-week period experienced a 36.6% reduction in plaque size compared to only an 11.5% reduction for the group who was given 20 mg of a statin.

Both groups noticed lower levels of bad cholesterol (LDL-C), total cholesterol, and triglycerides (fats), however, only the participants who were administered nattokinase were found to have heightened levels of good cholesterol (HDL-C).

These improvements were attributed to the ability of nattokinase to dissolve fibrin and fibrinogen, target thickened arteries and blood clots, and augment the activity of other substances in the body that have similar functions. Additionally, nattokinase is a proven alternative to traditional therapies when addressing cardiovascular risk factors associated with heightened fibrin levels.

The Heart Healthy Enzyme

Finally, research has shown that nattokinase reduces red blood cell clumping and undesirable blood clots by targeting both fibrin and fibrinogen. The result is improved blood flow. Cleaner blood is better for your body – and that’s how nattokinase helps to keep your body running in tip-top shape!

Nattokinase: The Lower Pressure Agent

Nattokinase’s ability to restore proper blood flow is one benefit that leads to another: lower blood pressure.

Clinical research by the Japan Functional Food Research Association documented an average 10.9% reduction of systolic blood pressure as well as an average 9.7% for diastolic pressure with nattokinase supplementation, helping to restore proper blood flow.

In another study with 39 individuals whose systolic blood pressure ranged from 130 mmHg to 159 mmHg, participants who were supplemented with nattokinase for 8 weeks, ended up with both lower systolic and diastolic blood pressure, compared to the placebo group. This demonstrates that nattokinase supports healthy blood pressure levels for people with elevated blood pressure approaching out of range.

Why Add Nattokinase to Your Supplement Routine?

According to The Applied Microbiology and Biotechnology, nattokinase remains stable in the GI tract and is a safe, strong nutraceutical and dietary supplement without serious adverse side effects.

Whether you’re battling – or susceptible to – clots, elevated blood pressure, cardiovascular problems, stiffened arteries, or excess fibrin build-up, nattokinase is a safe, effective supplement to assist with normal blood flow and fibrin degradation.

Where to find nattokinase

The following products have high concentrations of nattokinase, which assist in dissolving excess fibrin for better joint mobility, cleaner blood, and overall well-being.

Nattovena – Your pure nattokinase supplement for potent fibrin-degrading ability.

Neprinol – Cleanses the blood and supports proper joint and circulatory function.

Fibrovera – Supports normal fibrin activity through healthy hormone levels for women.


What is Nattokinase?

Nattokinase nat-oh-KAI-nase is an enzyme that was discovered within the popular Japanese food natto, a fermented soybean cheese. It is produced by a probiotic bacteria Bacillus subtilis found to grow naturally during the fermentation of soybeans. While the nattokinase probiotic was found to exist on soybeans the extracted enzyme does not actually contain soy or soy particles itself. Making it safe for individuals trying to avoid soy products to consume. This enzyme is well-researched and known for its ability to dissolve fibrin, a strong protein that assists with the blood-clotting process.

In fact, nattokinase has been found to be four times stronger than human plasmin, the native enzyme that breaks down fibrin and blood clots. Nattokinase currently holds the title for the most powerful fibrin-dissolving enzyme.

Let’s look at the different ways nattokinase can condition blood to support cardiovascular health. The three pillars of ideal blood conditioning require normal ranges of: clotting, pressure, and viscosity.

Nattokinase has an unmatched ability to break down proteins, particularly fibrin. Fibrin is the sticky webs that aggregate blood cells.

In a clinical study published by the Japan Bio Science Laboratory Co. Ltd, oral supplementation of nattokinase significantly increased the ability of other substances in the bloodstream to break down blood clots for two to eight hours. This was not the case for regular soybean supplementation the nattokinase enzyme provided the defining benefit in the participants’ bloodstream.

Furthermore, a 2003 study concerning blood clots in the leg, concluded that people who were at risk for clotting and preparing for a long flight – and also orally consumed nattokinase – experienced a significant reduction of blood clots and swelling in their arms and legs.

Circulation and Blood Flow

Nattokinase has an impressive track record for its ability to improve blood flow by breaking down fibrin. This aptly positions it for assisting with cardiovascular concerns, such as arterial elasticity, build-up of fibrin, and unfavorable hemorheology (flow).

Certain cardiovascular circumstances are hastened by reduced blood flow to vital organs. These may be prompted by increased fibrinogen (fibrin’s precursor), elasticity of the arteries, red blood cell clumping which thickens the blood, and blood clots.

The ability of nattokinase to dissolve excess fibrinogen as well as fibrin, makes it a heart-healthy supplement.

Heart Attention: A Nattokinase Clinical Study

In a 2017 clinical trial with over 80 participants who had carotid artery thickness and plaque buildup in the carotid artery (both indicators of atherosclerosis), the group who was given 6,000 FU of nattokinase over a 26-week period experienced a 36.6% reduction in plaque size compared to only an 11.5% reduction for the group who was given 20 mg of a statin.

Both groups noticed lower levels of bad cholesterol (LDL-C), total cholesterol, and triglycerides (fats), however, only the participants who were administered nattokinase were found to have heightened levels of good cholesterol (HDL-C).

These improvements were attributed to the ability of nattokinase to dissolve fibrin and fibrinogen, target thickened arteries and blood clots, and augment the activity of other substances in the body that have similar functions. Additionally, nattokinase is a proven alternative to traditional therapies when addressing cardiovascular risk factors associated with heightened fibrin levels.

The Heart Healthy Enzyme

Finally, research has shown that nattokinase reduces red blood cell clumping and undesirable blood clots by targeting both fibrin and fibrinogen. The result is improved blood flow. Cleaner blood is better for your body – and that’s how nattokinase helps to keep your body running in tip-top shape!

Nattokinase: The Lower Pressure Agent

Nattokinase’s ability to restore proper blood flow is one benefit that leads to another: lower blood pressure.

Clinical research by the Japan Functional Food Research Association documented an average 10.9% reduction of systolic blood pressure as well as an average 9.7% for diastolic pressure with nattokinase supplementation, helping to restore proper blood flow.

In another study with 39 individuals whose systolic blood pressure ranged from 130 mmHg to 159 mmHg, participants who were supplemented with nattokinase for 8 weeks, ended up with both lower systolic and diastolic blood pressure, compared to the placebo group. This demonstrates that nattokinase supports healthy blood pressure levels for people with elevated blood pressure approaching out of range.

Why Add Nattokinase to Your Supplement Routine?

According to The Applied Microbiology and Biotechnology, nattokinase remains stable in the GI tract and is a safe, strong nutraceutical and dietary supplement without serious adverse side effects.

Whether you’re battling – or susceptible to – clots, elevated blood pressure, cardiovascular problems, stiffened arteries, or excess fibrin build-up, nattokinase is a safe, effective supplement to assist with normal blood flow and fibrin degradation.

Where to find nattokinase

The following products have high concentrations of nattokinase, which assist in dissolving excess fibrin for better joint mobility, cleaner blood, and overall well-being.

Nattovena – Your pure nattokinase supplement for potent fibrin-degrading ability.

Neprinol – Cleanses the blood and supports proper joint and circulatory function.

Fibrovera – Supports normal fibrin activity through healthy hormone levels for women.


What is Nattokinase?

Nattokinase nat-oh-KAI-nase is an enzyme that was discovered within the popular Japanese food natto, a fermented soybean cheese. It is produced by a probiotic bacteria Bacillus subtilis found to grow naturally during the fermentation of soybeans. While the nattokinase probiotic was found to exist on soybeans the extracted enzyme does not actually contain soy or soy particles itself. Making it safe for individuals trying to avoid soy products to consume. This enzyme is well-researched and known for its ability to dissolve fibrin, a strong protein that assists with the blood-clotting process.

In fact, nattokinase has been found to be four times stronger than human plasmin, the native enzyme that breaks down fibrin and blood clots. Nattokinase currently holds the title for the most powerful fibrin-dissolving enzyme.

Let’s look at the different ways nattokinase can condition blood to support cardiovascular health. The three pillars of ideal blood conditioning require normal ranges of: clotting, pressure, and viscosity.

Nattokinase has an unmatched ability to break down proteins, particularly fibrin. Fibrin is the sticky webs that aggregate blood cells.

In a clinical study published by the Japan Bio Science Laboratory Co. Ltd, oral supplementation of nattokinase significantly increased the ability of other substances in the bloodstream to break down blood clots for two to eight hours. This was not the case for regular soybean supplementation the nattokinase enzyme provided the defining benefit in the participants’ bloodstream.

Furthermore, a 2003 study concerning blood clots in the leg, concluded that people who were at risk for clotting and preparing for a long flight – and also orally consumed nattokinase – experienced a significant reduction of blood clots and swelling in their arms and legs.

Circulation and Blood Flow

Nattokinase has an impressive track record for its ability to improve blood flow by breaking down fibrin. This aptly positions it for assisting with cardiovascular concerns, such as arterial elasticity, build-up of fibrin, and unfavorable hemorheology (flow).

Certain cardiovascular circumstances are hastened by reduced blood flow to vital organs. These may be prompted by increased fibrinogen (fibrin’s precursor), elasticity of the arteries, red blood cell clumping which thickens the blood, and blood clots.

The ability of nattokinase to dissolve excess fibrinogen as well as fibrin, makes it a heart-healthy supplement.

Heart Attention: A Nattokinase Clinical Study

In a 2017 clinical trial with over 80 participants who had carotid artery thickness and plaque buildup in the carotid artery (both indicators of atherosclerosis), the group who was given 6,000 FU of nattokinase over a 26-week period experienced a 36.6% reduction in plaque size compared to only an 11.5% reduction for the group who was given 20 mg of a statin.

Both groups noticed lower levels of bad cholesterol (LDL-C), total cholesterol, and triglycerides (fats), however, only the participants who were administered nattokinase were found to have heightened levels of good cholesterol (HDL-C).

These improvements were attributed to the ability of nattokinase to dissolve fibrin and fibrinogen, target thickened arteries and blood clots, and augment the activity of other substances in the body that have similar functions. Additionally, nattokinase is a proven alternative to traditional therapies when addressing cardiovascular risk factors associated with heightened fibrin levels.

The Heart Healthy Enzyme

Finally, research has shown that nattokinase reduces red blood cell clumping and undesirable blood clots by targeting both fibrin and fibrinogen. The result is improved blood flow. Cleaner blood is better for your body – and that’s how nattokinase helps to keep your body running in tip-top shape!

Nattokinase: The Lower Pressure Agent

Nattokinase’s ability to restore proper blood flow is one benefit that leads to another: lower blood pressure.

Clinical research by the Japan Functional Food Research Association documented an average 10.9% reduction of systolic blood pressure as well as an average 9.7% for diastolic pressure with nattokinase supplementation, helping to restore proper blood flow.

In another study with 39 individuals whose systolic blood pressure ranged from 130 mmHg to 159 mmHg, participants who were supplemented with nattokinase for 8 weeks, ended up with both lower systolic and diastolic blood pressure, compared to the placebo group. This demonstrates that nattokinase supports healthy blood pressure levels for people with elevated blood pressure approaching out of range.

Why Add Nattokinase to Your Supplement Routine?

According to The Applied Microbiology and Biotechnology, nattokinase remains stable in the GI tract and is a safe, strong nutraceutical and dietary supplement without serious adverse side effects.

Whether you’re battling – or susceptible to – clots, elevated blood pressure, cardiovascular problems, stiffened arteries, or excess fibrin build-up, nattokinase is a safe, effective supplement to assist with normal blood flow and fibrin degradation.

Where to find nattokinase

The following products have high concentrations of nattokinase, which assist in dissolving excess fibrin for better joint mobility, cleaner blood, and overall well-being.

Nattovena – Your pure nattokinase supplement for potent fibrin-degrading ability.

Neprinol – Cleanses the blood and supports proper joint and circulatory function.

Fibrovera – Supports normal fibrin activity through healthy hormone levels for women.


What is Nattokinase?

Nattokinase nat-oh-KAI-nase is an enzyme that was discovered within the popular Japanese food natto, a fermented soybean cheese. It is produced by a probiotic bacteria Bacillus subtilis found to grow naturally during the fermentation of soybeans. While the nattokinase probiotic was found to exist on soybeans the extracted enzyme does not actually contain soy or soy particles itself. Making it safe for individuals trying to avoid soy products to consume. This enzyme is well-researched and known for its ability to dissolve fibrin, a strong protein that assists with the blood-clotting process.

In fact, nattokinase has been found to be four times stronger than human plasmin, the native enzyme that breaks down fibrin and blood clots. Nattokinase currently holds the title for the most powerful fibrin-dissolving enzyme.

Let’s look at the different ways nattokinase can condition blood to support cardiovascular health. The three pillars of ideal blood conditioning require normal ranges of: clotting, pressure, and viscosity.

Nattokinase has an unmatched ability to break down proteins, particularly fibrin. Fibrin is the sticky webs that aggregate blood cells.

In a clinical study published by the Japan Bio Science Laboratory Co. Ltd, oral supplementation of nattokinase significantly increased the ability of other substances in the bloodstream to break down blood clots for two to eight hours. This was not the case for regular soybean supplementation the nattokinase enzyme provided the defining benefit in the participants’ bloodstream.

Furthermore, a 2003 study concerning blood clots in the leg, concluded that people who were at risk for clotting and preparing for a long flight – and also orally consumed nattokinase – experienced a significant reduction of blood clots and swelling in their arms and legs.

Circulation and Blood Flow

Nattokinase has an impressive track record for its ability to improve blood flow by breaking down fibrin. This aptly positions it for assisting with cardiovascular concerns, such as arterial elasticity, build-up of fibrin, and unfavorable hemorheology (flow).

Certain cardiovascular circumstances are hastened by reduced blood flow to vital organs. These may be prompted by increased fibrinogen (fibrin’s precursor), elasticity of the arteries, red blood cell clumping which thickens the blood, and blood clots.

The ability of nattokinase to dissolve excess fibrinogen as well as fibrin, makes it a heart-healthy supplement.

Heart Attention: A Nattokinase Clinical Study

In a 2017 clinical trial with over 80 participants who had carotid artery thickness and plaque buildup in the carotid artery (both indicators of atherosclerosis), the group who was given 6,000 FU of nattokinase over a 26-week period experienced a 36.6% reduction in plaque size compared to only an 11.5% reduction for the group who was given 20 mg of a statin.

Both groups noticed lower levels of bad cholesterol (LDL-C), total cholesterol, and triglycerides (fats), however, only the participants who were administered nattokinase were found to have heightened levels of good cholesterol (HDL-C).

These improvements were attributed to the ability of nattokinase to dissolve fibrin and fibrinogen, target thickened arteries and blood clots, and augment the activity of other substances in the body that have similar functions. Additionally, nattokinase is a proven alternative to traditional therapies when addressing cardiovascular risk factors associated with heightened fibrin levels.

The Heart Healthy Enzyme

Finally, research has shown that nattokinase reduces red blood cell clumping and undesirable blood clots by targeting both fibrin and fibrinogen. The result is improved blood flow. Cleaner blood is better for your body – and that’s how nattokinase helps to keep your body running in tip-top shape!

Nattokinase: The Lower Pressure Agent

Nattokinase’s ability to restore proper blood flow is one benefit that leads to another: lower blood pressure.

Clinical research by the Japan Functional Food Research Association documented an average 10.9% reduction of systolic blood pressure as well as an average 9.7% for diastolic pressure with nattokinase supplementation, helping to restore proper blood flow.

In another study with 39 individuals whose systolic blood pressure ranged from 130 mmHg to 159 mmHg, participants who were supplemented with nattokinase for 8 weeks, ended up with both lower systolic and diastolic blood pressure, compared to the placebo group. This demonstrates that nattokinase supports healthy blood pressure levels for people with elevated blood pressure approaching out of range.

Why Add Nattokinase to Your Supplement Routine?

According to The Applied Microbiology and Biotechnology, nattokinase remains stable in the GI tract and is a safe, strong nutraceutical and dietary supplement without serious adverse side effects.

Whether you’re battling – or susceptible to – clots, elevated blood pressure, cardiovascular problems, stiffened arteries, or excess fibrin build-up, nattokinase is a safe, effective supplement to assist with normal blood flow and fibrin degradation.

Where to find nattokinase

The following products have high concentrations of nattokinase, which assist in dissolving excess fibrin for better joint mobility, cleaner blood, and overall well-being.

Nattovena – Your pure nattokinase supplement for potent fibrin-degrading ability.

Neprinol – Cleanses the blood and supports proper joint and circulatory function.

Fibrovera – Supports normal fibrin activity through healthy hormone levels for women.


What is Nattokinase?

Nattokinase nat-oh-KAI-nase is an enzyme that was discovered within the popular Japanese food natto, a fermented soybean cheese. It is produced by a probiotic bacteria Bacillus subtilis found to grow naturally during the fermentation of soybeans. While the nattokinase probiotic was found to exist on soybeans the extracted enzyme does not actually contain soy or soy particles itself. Making it safe for individuals trying to avoid soy products to consume. This enzyme is well-researched and known for its ability to dissolve fibrin, a strong protein that assists with the blood-clotting process.

In fact, nattokinase has been found to be four times stronger than human plasmin, the native enzyme that breaks down fibrin and blood clots. Nattokinase currently holds the title for the most powerful fibrin-dissolving enzyme.

Let’s look at the different ways nattokinase can condition blood to support cardiovascular health. The three pillars of ideal blood conditioning require normal ranges of: clotting, pressure, and viscosity.

Nattokinase has an unmatched ability to break down proteins, particularly fibrin. Fibrin is the sticky webs that aggregate blood cells.

In a clinical study published by the Japan Bio Science Laboratory Co. Ltd, oral supplementation of nattokinase significantly increased the ability of other substances in the bloodstream to break down blood clots for two to eight hours. This was not the case for regular soybean supplementation the nattokinase enzyme provided the defining benefit in the participants’ bloodstream.

Furthermore, a 2003 study concerning blood clots in the leg, concluded that people who were at risk for clotting and preparing for a long flight – and also orally consumed nattokinase – experienced a significant reduction of blood clots and swelling in their arms and legs.

Circulation and Blood Flow

Nattokinase has an impressive track record for its ability to improve blood flow by breaking down fibrin. This aptly positions it for assisting with cardiovascular concerns, such as arterial elasticity, build-up of fibrin, and unfavorable hemorheology (flow).

Certain cardiovascular circumstances are hastened by reduced blood flow to vital organs. These may be prompted by increased fibrinogen (fibrin’s precursor), elasticity of the arteries, red blood cell clumping which thickens the blood, and blood clots.

The ability of nattokinase to dissolve excess fibrinogen as well as fibrin, makes it a heart-healthy supplement.

Heart Attention: A Nattokinase Clinical Study

In a 2017 clinical trial with over 80 participants who had carotid artery thickness and plaque buildup in the carotid artery (both indicators of atherosclerosis), the group who was given 6,000 FU of nattokinase over a 26-week period experienced a 36.6% reduction in plaque size compared to only an 11.5% reduction for the group who was given 20 mg of a statin.

Both groups noticed lower levels of bad cholesterol (LDL-C), total cholesterol, and triglycerides (fats), however, only the participants who were administered nattokinase were found to have heightened levels of good cholesterol (HDL-C).

These improvements were attributed to the ability of nattokinase to dissolve fibrin and fibrinogen, target thickened arteries and blood clots, and augment the activity of other substances in the body that have similar functions. Additionally, nattokinase is a proven alternative to traditional therapies when addressing cardiovascular risk factors associated with heightened fibrin levels.

The Heart Healthy Enzyme

Finally, research has shown that nattokinase reduces red blood cell clumping and undesirable blood clots by targeting both fibrin and fibrinogen. The result is improved blood flow. Cleaner blood is better for your body – and that’s how nattokinase helps to keep your body running in tip-top shape!

Nattokinase: The Lower Pressure Agent

Nattokinase’s ability to restore proper blood flow is one benefit that leads to another: lower blood pressure.

Clinical research by the Japan Functional Food Research Association documented an average 10.9% reduction of systolic blood pressure as well as an average 9.7% for diastolic pressure with nattokinase supplementation, helping to restore proper blood flow.

In another study with 39 individuals whose systolic blood pressure ranged from 130 mmHg to 159 mmHg, participants who were supplemented with nattokinase for 8 weeks, ended up with both lower systolic and diastolic blood pressure, compared to the placebo group. This demonstrates that nattokinase supports healthy blood pressure levels for people with elevated blood pressure approaching out of range.

Why Add Nattokinase to Your Supplement Routine?

According to The Applied Microbiology and Biotechnology, nattokinase remains stable in the GI tract and is a safe, strong nutraceutical and dietary supplement without serious adverse side effects.

Whether you’re battling – or susceptible to – clots, elevated blood pressure, cardiovascular problems, stiffened arteries, or excess fibrin build-up, nattokinase is a safe, effective supplement to assist with normal blood flow and fibrin degradation.

Where to find nattokinase

The following products have high concentrations of nattokinase, which assist in dissolving excess fibrin for better joint mobility, cleaner blood, and overall well-being.

Nattovena – Your pure nattokinase supplement for potent fibrin-degrading ability.

Neprinol – Cleanses the blood and supports proper joint and circulatory function.

Fibrovera – Supports normal fibrin activity through healthy hormone levels for women.


What is Nattokinase?

Nattokinase nat-oh-KAI-nase is an enzyme that was discovered within the popular Japanese food natto, a fermented soybean cheese. It is produced by a probiotic bacteria Bacillus subtilis found to grow naturally during the fermentation of soybeans. While the nattokinase probiotic was found to exist on soybeans the extracted enzyme does not actually contain soy or soy particles itself. Making it safe for individuals trying to avoid soy products to consume. This enzyme is well-researched and known for its ability to dissolve fibrin, a strong protein that assists with the blood-clotting process.

In fact, nattokinase has been found to be four times stronger than human plasmin, the native enzyme that breaks down fibrin and blood clots. Nattokinase currently holds the title for the most powerful fibrin-dissolving enzyme.

Let’s look at the different ways nattokinase can condition blood to support cardiovascular health. The three pillars of ideal blood conditioning require normal ranges of: clotting, pressure, and viscosity.

Nattokinase has an unmatched ability to break down proteins, particularly fibrin. Fibrin is the sticky webs that aggregate blood cells.

In a clinical study published by the Japan Bio Science Laboratory Co. Ltd, oral supplementation of nattokinase significantly increased the ability of other substances in the bloodstream to break down blood clots for two to eight hours. This was not the case for regular soybean supplementation the nattokinase enzyme provided the defining benefit in the participants’ bloodstream.

Furthermore, a 2003 study concerning blood clots in the leg, concluded that people who were at risk for clotting and preparing for a long flight – and also orally consumed nattokinase – experienced a significant reduction of blood clots and swelling in their arms and legs.

Circulation and Blood Flow

Nattokinase has an impressive track record for its ability to improve blood flow by breaking down fibrin. This aptly positions it for assisting with cardiovascular concerns, such as arterial elasticity, build-up of fibrin, and unfavorable hemorheology (flow).

Certain cardiovascular circumstances are hastened by reduced blood flow to vital organs. These may be prompted by increased fibrinogen (fibrin’s precursor), elasticity of the arteries, red blood cell clumping which thickens the blood, and blood clots.

The ability of nattokinase to dissolve excess fibrinogen as well as fibrin, makes it a heart-healthy supplement.

Heart Attention: A Nattokinase Clinical Study

In a 2017 clinical trial with over 80 participants who had carotid artery thickness and plaque buildup in the carotid artery (both indicators of atherosclerosis), the group who was given 6,000 FU of nattokinase over a 26-week period experienced a 36.6% reduction in plaque size compared to only an 11.5% reduction for the group who was given 20 mg of a statin.

Both groups noticed lower levels of bad cholesterol (LDL-C), total cholesterol, and triglycerides (fats), however, only the participants who were administered nattokinase were found to have heightened levels of good cholesterol (HDL-C).

These improvements were attributed to the ability of nattokinase to dissolve fibrin and fibrinogen, target thickened arteries and blood clots, and augment the activity of other substances in the body that have similar functions. Additionally, nattokinase is a proven alternative to traditional therapies when addressing cardiovascular risk factors associated with heightened fibrin levels.

The Heart Healthy Enzyme

Finally, research has shown that nattokinase reduces red blood cell clumping and undesirable blood clots by targeting both fibrin and fibrinogen. The result is improved blood flow. Cleaner blood is better for your body – and that’s how nattokinase helps to keep your body running in tip-top shape!

Nattokinase: The Lower Pressure Agent

Nattokinase’s ability to restore proper blood flow is one benefit that leads to another: lower blood pressure.

Clinical research by the Japan Functional Food Research Association documented an average 10.9% reduction of systolic blood pressure as well as an average 9.7% for diastolic pressure with nattokinase supplementation, helping to restore proper blood flow.

In another study with 39 individuals whose systolic blood pressure ranged from 130 mmHg to 159 mmHg, participants who were supplemented with nattokinase for 8 weeks, ended up with both lower systolic and diastolic blood pressure, compared to the placebo group. This demonstrates that nattokinase supports healthy blood pressure levels for people with elevated blood pressure approaching out of range.

Why Add Nattokinase to Your Supplement Routine?

According to The Applied Microbiology and Biotechnology, nattokinase remains stable in the GI tract and is a safe, strong nutraceutical and dietary supplement without serious adverse side effects.

Whether you’re battling – or susceptible to – clots, elevated blood pressure, cardiovascular problems, stiffened arteries, or excess fibrin build-up, nattokinase is a safe, effective supplement to assist with normal blood flow and fibrin degradation.

Where to find nattokinase

The following products have high concentrations of nattokinase, which assist in dissolving excess fibrin for better joint mobility, cleaner blood, and overall well-being.

Nattovena – Your pure nattokinase supplement for potent fibrin-degrading ability.

Neprinol – Cleanses the blood and supports proper joint and circulatory function.

Fibrovera – Supports normal fibrin activity through healthy hormone levels for women.


What is Nattokinase?

Nattokinase nat-oh-KAI-nase is an enzyme that was discovered within the popular Japanese food natto, a fermented soybean cheese. It is produced by a probiotic bacteria Bacillus subtilis found to grow naturally during the fermentation of soybeans. While the nattokinase probiotic was found to exist on soybeans the extracted enzyme does not actually contain soy or soy particles itself. Making it safe for individuals trying to avoid soy products to consume. This enzyme is well-researched and known for its ability to dissolve fibrin, a strong protein that assists with the blood-clotting process.

In fact, nattokinase has been found to be four times stronger than human plasmin, the native enzyme that breaks down fibrin and blood clots. Nattokinase currently holds the title for the most powerful fibrin-dissolving enzyme.

Let’s look at the different ways nattokinase can condition blood to support cardiovascular health. The three pillars of ideal blood conditioning require normal ranges of: clotting, pressure, and viscosity.

Nattokinase has an unmatched ability to break down proteins, particularly fibrin. Fibrin is the sticky webs that aggregate blood cells.

In a clinical study published by the Japan Bio Science Laboratory Co. Ltd, oral supplementation of nattokinase significantly increased the ability of other substances in the bloodstream to break down blood clots for two to eight hours. This was not the case for regular soybean supplementation the nattokinase enzyme provided the defining benefit in the participants’ bloodstream.

Furthermore, a 2003 study concerning blood clots in the leg, concluded that people who were at risk for clotting and preparing for a long flight – and also orally consumed nattokinase – experienced a significant reduction of blood clots and swelling in their arms and legs.

Circulation and Blood Flow

Nattokinase has an impressive track record for its ability to improve blood flow by breaking down fibrin. This aptly positions it for assisting with cardiovascular concerns, such as arterial elasticity, build-up of fibrin, and unfavorable hemorheology (flow).

Certain cardiovascular circumstances are hastened by reduced blood flow to vital organs. These may be prompted by increased fibrinogen (fibrin’s precursor), elasticity of the arteries, red blood cell clumping which thickens the blood, and blood clots.

The ability of nattokinase to dissolve excess fibrinogen as well as fibrin, makes it a heart-healthy supplement.

Heart Attention: A Nattokinase Clinical Study

In a 2017 clinical trial with over 80 participants who had carotid artery thickness and plaque buildup in the carotid artery (both indicators of atherosclerosis), the group who was given 6,000 FU of nattokinase over a 26-week period experienced a 36.6% reduction in plaque size compared to only an 11.5% reduction for the group who was given 20 mg of a statin.

Both groups noticed lower levels of bad cholesterol (LDL-C), total cholesterol, and triglycerides (fats), however, only the participants who were administered nattokinase were found to have heightened levels of good cholesterol (HDL-C).

These improvements were attributed to the ability of nattokinase to dissolve fibrin and fibrinogen, target thickened arteries and blood clots, and augment the activity of other substances in the body that have similar functions. Additionally, nattokinase is a proven alternative to traditional therapies when addressing cardiovascular risk factors associated with heightened fibrin levels.

The Heart Healthy Enzyme

Finally, research has shown that nattokinase reduces red blood cell clumping and undesirable blood clots by targeting both fibrin and fibrinogen. The result is improved blood flow. Cleaner blood is better for your body – and that’s how nattokinase helps to keep your body running in tip-top shape!

Nattokinase: The Lower Pressure Agent

Nattokinase’s ability to restore proper blood flow is one benefit that leads to another: lower blood pressure.

Clinical research by the Japan Functional Food Research Association documented an average 10.9% reduction of systolic blood pressure as well as an average 9.7% for diastolic pressure with nattokinase supplementation, helping to restore proper blood flow.

In another study with 39 individuals whose systolic blood pressure ranged from 130 mmHg to 159 mmHg, participants who were supplemented with nattokinase for 8 weeks, ended up with both lower systolic and diastolic blood pressure, compared to the placebo group. This demonstrates that nattokinase supports healthy blood pressure levels for people with elevated blood pressure approaching out of range.

Why Add Nattokinase to Your Supplement Routine?

According to The Applied Microbiology and Biotechnology, nattokinase remains stable in the GI tract and is a safe, strong nutraceutical and dietary supplement without serious adverse side effects.

Whether you’re battling – or susceptible to – clots, elevated blood pressure, cardiovascular problems, stiffened arteries, or excess fibrin build-up, nattokinase is a safe, effective supplement to assist with normal blood flow and fibrin degradation.

Where to find nattokinase

The following products have high concentrations of nattokinase, which assist in dissolving excess fibrin for better joint mobility, cleaner blood, and overall well-being.

Nattovena – Your pure nattokinase supplement for potent fibrin-degrading ability.

Neprinol – Cleanses the blood and supports proper joint and circulatory function.

Fibrovera – Supports normal fibrin activity through healthy hormone levels for women.


What is Nattokinase?

Nattokinase nat-oh-KAI-nase is an enzyme that was discovered within the popular Japanese food natto, a fermented soybean cheese. It is produced by a probiotic bacteria Bacillus subtilis found to grow naturally during the fermentation of soybeans. While the nattokinase probiotic was found to exist on soybeans the extracted enzyme does not actually contain soy or soy particles itself. Making it safe for individuals trying to avoid soy products to consume. This enzyme is well-researched and known for its ability to dissolve fibrin, a strong protein that assists with the blood-clotting process.

In fact, nattokinase has been found to be four times stronger than human plasmin, the native enzyme that breaks down fibrin and blood clots. Nattokinase currently holds the title for the most powerful fibrin-dissolving enzyme.

Let’s look at the different ways nattokinase can condition blood to support cardiovascular health. The three pillars of ideal blood conditioning require normal ranges of: clotting, pressure, and viscosity.

Nattokinase has an unmatched ability to break down proteins, particularly fibrin. Fibrin is the sticky webs that aggregate blood cells.

In a clinical study published by the Japan Bio Science Laboratory Co. Ltd, oral supplementation of nattokinase significantly increased the ability of other substances in the bloodstream to break down blood clots for two to eight hours. This was not the case for regular soybean supplementation the nattokinase enzyme provided the defining benefit in the participants’ bloodstream.

Furthermore, a 2003 study concerning blood clots in the leg, concluded that people who were at risk for clotting and preparing for a long flight – and also orally consumed nattokinase – experienced a significant reduction of blood clots and swelling in their arms and legs.

Circulation and Blood Flow

Nattokinase has an impressive track record for its ability to improve blood flow by breaking down fibrin. This aptly positions it for assisting with cardiovascular concerns, such as arterial elasticity, build-up of fibrin, and unfavorable hemorheology (flow).

Certain cardiovascular circumstances are hastened by reduced blood flow to vital organs. These may be prompted by increased fibrinogen (fibrin’s precursor), elasticity of the arteries, red blood cell clumping which thickens the blood, and blood clots.

The ability of nattokinase to dissolve excess fibrinogen as well as fibrin, makes it a heart-healthy supplement.

Heart Attention: A Nattokinase Clinical Study

In a 2017 clinical trial with over 80 participants who had carotid artery thickness and plaque buildup in the carotid artery (both indicators of atherosclerosis), the group who was given 6,000 FU of nattokinase over a 26-week period experienced a 36.6% reduction in plaque size compared to only an 11.5% reduction for the group who was given 20 mg of a statin.

Both groups noticed lower levels of bad cholesterol (LDL-C), total cholesterol, and triglycerides (fats), however, only the participants who were administered nattokinase were found to have heightened levels of good cholesterol (HDL-C).

These improvements were attributed to the ability of nattokinase to dissolve fibrin and fibrinogen, target thickened arteries and blood clots, and augment the activity of other substances in the body that have similar functions. Additionally, nattokinase is a proven alternative to traditional therapies when addressing cardiovascular risk factors associated with heightened fibrin levels.

The Heart Healthy Enzyme

Finally, research has shown that nattokinase reduces red blood cell clumping and undesirable blood clots by targeting both fibrin and fibrinogen. The result is improved blood flow. Cleaner blood is better for your body – and that’s how nattokinase helps to keep your body running in tip-top shape!

Nattokinase: The Lower Pressure Agent

Nattokinase’s ability to restore proper blood flow is one benefit that leads to another: lower blood pressure.

Clinical research by the Japan Functional Food Research Association documented an average 10.9% reduction of systolic blood pressure as well as an average 9.7% for diastolic pressure with nattokinase supplementation, helping to restore proper blood flow.

In another study with 39 individuals whose systolic blood pressure ranged from 130 mmHg to 159 mmHg, participants who were supplemented with nattokinase for 8 weeks, ended up with both lower systolic and diastolic blood pressure, compared to the placebo group. This demonstrates that nattokinase supports healthy blood pressure levels for people with elevated blood pressure approaching out of range.

Why Add Nattokinase to Your Supplement Routine?

According to The Applied Microbiology and Biotechnology, nattokinase remains stable in the GI tract and is a safe, strong nutraceutical and dietary supplement without serious adverse side effects.

Whether you’re battling – or susceptible to – clots, elevated blood pressure, cardiovascular problems, stiffened arteries, or excess fibrin build-up, nattokinase is a safe, effective supplement to assist with normal blood flow and fibrin degradation.

Where to find nattokinase

The following products have high concentrations of nattokinase, which assist in dissolving excess fibrin for better joint mobility, cleaner blood, and overall well-being.

Nattovena – Your pure nattokinase supplement for potent fibrin-degrading ability.

Neprinol – Cleanses the blood and supports proper joint and circulatory function.

Fibrovera – Supports normal fibrin activity through healthy hormone levels for women.